Sodium Hydroxide → HCID 20061667, compound

HRID 1608167Notes

Reaction equation

HRID 1608167 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][CH2:12][CH2:13][C:14]2[N:15]([CH3:25])[C:16]([CH2:19][C:20]([O:22]CC)=[O:21])=[CH:17][CH:18]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[OH-].[Na+]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][CH2:12][CH2:13][C:14]2[N:15]([CH3:25])[C:16]([CH2:19][C:20]([OH:22])=[O:21])=[CH:17][CH:18]=2)(=[O:9])=[O:10])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 54187262HCID 54187262, compound

Product 1

HCID 20061667HCID 20061667, compound

Procedure

0.5 g (1.3 mmol) of ethyl [2-(2-(4-fluorobenzenesulphonylamino)-ethyl)-1-methylpyrrol-5-yl]acetate are stirred into 4.5 ml of 1N of sodium hydroxide solution overnight at ambient temperature. The mixture is then extracted with ethylene chloride and the aqueous phase is acidified with 1N hydrochloric acid. The precipitate obtained is suction filtered and dried.

Workup

  1. extractionThe mixture is then extracted with ethylene chloride
  2. customThe precipitate obtained
  3. filtrationfiltered
  4. customdried

Sources & evidence

ORD record
ord-72c116df245a44038d25934c85cd46f7
Source dataset
uspto-grants-1989_09
Patent number
US04870076

Reaction notes

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