Propane sultone → HCID 8445804, compound

HRID 1608170Notes

Reaction equation

HRID 1608170 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1.[CH2:14]1[CH2:20][S:17](=[O:19])(=[O:18])[O:16][CH2:15]1>>[S:17]([CH2:20][CH2:14][CH2:15][N:11]1[CH2:12][CH2:13][N:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[Cl:1])[CH2:9][CH2:10]1)([OH:19])(=[O:18])=[O:16]

Participants

3

Reactant 2

HCID 14264Propane sultoneHCID 4156281-(2-Chlorophenyl)piperazine

Product 1

HCID 8445804HCID 8445804, compound

Procedure

The reaction is conducted in the same manner as in Example 4 except that 4.2 g (21.4 mmols) of 1-(o-chlorophenyl)piperazine and 3.2 g (26.2 mmols) of 1,3-propanesultone are used. The resulting product is recrystallized from water.

Workup

  1. customThe resulting product is recrystallized from water

Sources & evidence

ORD record
ord-5aac086f79a94dc88c28665257c7ca9a
Source dataset
uspto-grants-1989_09
Patent number
US04870078

Reaction notes

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