Hydrazinecarboxylic acid, ethyl ester → HCID 53882320, compound

HRID 1608180Notes

Reaction equation

HRID 1608180 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH:11]=O.[CH2:13]([O:15][C:16](=[O:19])[NH:17][NH2:18])[CH3:14]>CO>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH:11]=[N:18][NH:17][C:16]([O:15][CH2:13][CH3:14])=[O:19]

Participants

4

Reactant 2

HCID 20064Hydrazinecarboxylic acid, ethyl esterHCID 796192-Quinolinecarboxaldehyde

Product 1

HCID 53882320HCID 53882320, compoundYield 20%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 3.93 gm (0.025 mole) of 2-quinolinecarboxaldehyde, 2.60 gm (0.025 mole) of ethylcarbazate and 100 ml of methanol is refluxed for 8 hrs. The hot solvent is evaporated in vacuo to give a solid. The crude product is crystallized from ethyl acetate/Skellysolve B to yield 1.19 gm (20%) of the title compound, having a melting point of 163°-165° C.

Workup

  1. temperatureis refluxed for 8 hrs
  2. customThe hot solvent is evaporated in vacuo
  3. customto give a solid
  4. customThe crude product is crystallized from ethyl acetate/Skellysolve B

Sources & evidence

ORD record
ord-42f7745237f342f7898fab889b608753
Source dataset
uspto-grants-1989_09
Patent number
US04870082

Reaction notes

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