4-Amino-5-chloro-2-methoxybenzoic acid → HCID 14881838, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 2-(3-aminopropyl)-4-benzylmorpholine (2.0 g), 4-amino-5-chloro-2-methoxybenzoic acid (1.7 g) and dichloromethane (40 ml), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (1.8 g) is added, and the mixture is stirred at 25° C. for 4 hours. The reaction mixture is washed successively with water, 10% aqueous sodium hydroxide solution and saturated aqueous sodium chloride solution, dried over magnesium sulfate, and evaporated under reduced pressure. The residue is dissolved in chloroform and chromatographed on silica gel. The eluate with chloroform is discarded, and the subsequent eluates with methanol-chloroform (1:9) are pooled and evaporated to give the title compound (2.5 g) as an oil.

Provenance & Evidence