4-Amino-5-chloro-2-methoxybenzoic acid → 2,3-methylenedioxy-N-[(4-benzyl-2-morpholinyl)methyl]benzamide

Participants

Reaction Steps

The title compound is prepared in substantially the same manner as in Example 6(1), using 2-aminomethyl-4-benzylmorpholine and 2,3-methylenedioxybenzoic acid, respectively, in place of 2-aminomethyl-4-(4-cyanobenzyl)morpholine and 4-amino-5-chloro-2-methoxybenzoic acid in Example 6(1). The free base thus obtained is treated in substantially the same manner as in Example 6(2) to give the fumarate 1/4 hydrate of the title compound, mp 144°-146° C. (recrystallized from ethanol).

Provenance & Evidence