Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | 4-Benzyl-2-(chloromethyl)morpholine | HCID 2801562 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 19848617 | HCID 19848617 | 97.2% |
Reaction Steps
A mixture of 4-benzyl-2-chloromethylmorpholine (15.0 g), sodium azide (8.6 g), and dimethylformamide (150 ml) is stirred at 130° C. for 2 hours. The reaction mixture is diluted with water and extracted with diethyl ether. The organic layer is washed successively with water and saturated aqueous sodium chloride solution, and dried over magnesium sulfate. The solvent is distilled off under reduced pressure to give 2-azidomethyl-4-benzylmorpholine (15 g) as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04870074 |
|---|
| Source dataset | uspto-grants-1989_09 |
|---|
| ORD ID | ord-dfe55ac9d734434aa98ae35a3c160b17 |
|---|
| Source note | uspto-grants-1989_09 |
|---|
