Ethanol → HCID 19848597, compound

HRID 1608219Notes

Reaction equation

HRID 1608219 reaction equation
C([O:4][CH2:5][CH2:6][CH:7]1[O:12][CH2:11][CH2:10][N:9]([C:13]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:14])[CH2:8]1)(=O)C.[OH-].[K+].C(O)C>O>[OH:4][CH2:5][CH2:6][CH:7]1[O:12][CH2:11][CH2:10][N:9]([C:13]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:14])[CH2:8]1

Participants

5

Reactant 3

HCID 702EthanolHCID 14797Potassium HydroxideHCID 19848607Phenylmethyl 2-[2-(acetyloxy)ethyl]-4-morpholinecarboxylate

Product 1

HCID 19848597HCID 19848597, compoundYield 70.9%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 2-(2-acetoxyethyl)-4-benzyloxycarbonylmorpholine (24.5 g), potassium hydroxide (8.9 g), ethanol (40 ml), and water (40 ml) is refluxed for 30 minutes and concentrated under reduced pressure. Water is added to the residue and the mixture is extracted with diethyl ether. The organic layer is washed with water, dried over sodium sulfate, and evaporated to give the title compound (15 g) as an oil.

Workup

  1. temperatureis refluxed for 30 minutes
  2. concentrationconcentrated under reduced pressure
  3. additionWater is added to the residue
  4. extractionthe mixture is extracted with diethyl ether
  5. washThe organic layer is washed with water
  6. dry with materialdried over sodium sulfate
  7. customevaporated

Sources & evidence

ORD record
ord-edb069b8cef14e5eb3fb84cb65bbe40a
Source dataset
uspto-grants-1989_09
Patent number
US04870074

Reaction notes

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