Pyridinium chloride → HCID 13327016, compound

HRID 1608240Notes

Reaction equation

HRID 1608240 reaction equation
Cl.[S:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7]1[CH2:8][CH2:9][N:10]([CH2:13][CH2:14][CH2:15][CH2:16][C:17]2[C:25]3[C:20](=[CH:21][C:22]([O:26]C)=[CH:23][CH:24]=3)[NH:19][CH:18]=2)[CH2:11][CH:12]=1.Cl.N1C=CC=CC=1>>[S:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7]1[CH2:8][CH2:9][N:10]([CH2:13][CH2:14][CH2:15][CH2:16][C:17]2[C:25]3[C:20](=[CH:21][C:22]([OH:26])=[CH:23][CH:24]=3)[NH:19][CH:18]=2)[CH2:11][CH:12]=1

Participants

3

Reactant 2

HCID 10176127Pyridinium chlorideHCID 70395592HCID 70395592, compound

Product 1

HCID 13327016HCID 13327016, compound

Procedure

A mixture of 4.03 g of 3-[4-(4-(2-thienyl)-1,2,3,6-tetrahydropyridyl)butyl]-6-methoxyindole hydrochloride and 3.5 g of pyridine hydrochloride is stirred at 160° for 3 hours. After the usual work-up, 3-[4-(4-(2-thienyl)-1,2,3,6-tetrahydropyridyl)butyl]-6-hydroxyindole of m.p. 181° is obtained.

Sources & evidence

ORD record
ord-31773d95ecd3405aa5dbd66bbdadd747
Source dataset
uspto-grants-1989_09
Patent number
US04870087

Reaction notes

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