1H-1,2,4-Triazole → Tebuconazole

Participants

Reaction Steps

A solution of 17.9 g (0.075 mole) of 2-(4-chlorophenyl-ethyl)-2-tert.-butyl-oxirane and 6.9 g (0.1 mole) of 1,2,4-triazole in 30 ml of ethanol were heated at 150° C. in a bomb tube for 20 hours. The reaction mixture was allowed to cool and was concentrated. The residue was dissolved in ether and the ether solution was washed three times with water and once with sodium chloride solution, dried over sodium sulphate and concentrated. The residue was chromatographed over a silica gel column (mobile phase: methylene chloride/ethyl acetate 1:1). 12.3 g (53.2% of theory) of 1-(4-chlorophenyl)-4,4-dimethyl-3-(1,2,4-triazol-1-yl-methyl)-pentan-3-ol were obtained as a viscous oil.

Provenance & Evidence