HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2,2-Trifluoro-N-methoxy-N-methylacetamide → 1-(2,2,3,3-Tetrafluorobenzofuran-5-yl)-2,2,2-trifluoroethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2,2-Trifluoro-N-methoxy-N-methylacetamide | HCID 2782382 | — |
| Reactant | Magnesium | HCID 5462224 | — |
| Reactant | 5-Bromo-2,2,3,3-tetrafluorobenzofuran | HCID 14298496 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 1-(2,2,3,3-Tetrafluorobenzofuran-5-yl)-2,2,2-trifluoroethanone | HCID 14626963 | 92% |
Reaction Steps
The reaction of 5-bromo-2,2,3,3-tetrafluorobenzofuran (5.3 g, 0.02 mole) with magnesium turnings (0.48 g) in dry diethyl ether was followed by reaction with N-methoxy-N-methyltrifluoroacetamide (3.5 g, 0.022 mole), yielding 5.3 g of 1-(2,2,3,3-tetrafluorobenzofuran-5-yl)-2,2,2-trifluoroethanone.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04870089 |
| Source dataset | uspto-grants-1989_09 |
| ORD ID | ord-07eee027d42744c7b98e2970c1771e41 |
| Source note | uspto-grants-1989_09 |