Sodium Carbonate → N-[2-(4-Fluorophenyl)ethylidene]hydroxylamine

Participants

Reaction Steps

113 g of hydroxylammonium chloride in 300 ml of water are added to 160 g of p-fluorophenylacetaldehyde in 500 ml of methylene chloride. A solution of 87 g of sodium carbonate in 300 ml of water is slowly added dropwise to the stirred mixture at room temperature, and the reaction is allowed to continue for 2 days. The organic phase is separated off, washed with water, dried over Na2SO4 and filtered, and the filtrate is freed from the solvent. 161 g of p-fluorophenylacetaldoxime of melting point 113°-115° C. are obtained. 200 MHz NMR spectrum in CDCl3 : ##STR10## (cis/trans isomer mixture=1:1)

Provenance & Evidence