Potassium Hydroxide → HCID 13883256, compound

Participants

Reaction Steps

A solution of 58.3 g of KOH in 900 ml of ethanol is added to 138 g of 3-(p-fluorobenzyl)-5,5-bis-(acetoxymethyl)-isoxazoline, and the mixture is refluxed for 12 hours. After the mixture has been cooled, the precipitated salt is filtered off and the solvent is removed under reduced pressure. Acetone is added, after which precipitated solid is again filtered off under suction and the filtrate is evaporated down. The oil obtained can be purified by column chromatography [silica gel; eluent: toluene/acetone (initially 9/1, subsequently 1/1)]. 83 g of 3-(p-fluorobenzyl)-5,5-bis-(hydroxymethyl)-isoxazoline of melting point 93°-97° C. are obtained. ##STR12##

Provenance & Evidence