HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium hydroxide, monohydrate → HCID 19849007, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium hydroxide, monohydrate | HCID 168937 | — |
| Reactant | Methyl 3-{3-[2-(dimethylamino)ethyl]-1H-indol-5-yl}propanoate | HCID 19848998 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 19849007 | HCID 19849007 | — |
Reaction Steps
A mixture of Methyl 3-[2-(Dimethylamino)ethyl]-1H-indole-5-propanoate (4.6 g) and lithium hydroxide hydrate (0.7 g) in aqueous methanol (1:1) (80 ml) was stirred under reflux for 4.5 h. The solvent was removed by evaporation to leave a foam which was purified by flash chromatography (E). Evaporation of the appropriate fractions gave a solid which was triturated with ether to present the title compound as a powder (2.92 g) m.p. 195°-200°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04870096 |
| Source dataset | uspto-grants-1989_09 |
| ORD ID | ord-cf443b7003ae42c8b12b36a28dc37dd5 |
| Source note | uspto-grants-1989_09 |