Thionyl Chloride → Ethyl 2-(chloromethyl)-1,4-dithiaspiro[4.5]decane-7-acetate

Participants

Reaction Steps

The titled compound was prepared according to the procedure described in Example E using 6.2 g (0.021 mole) of the product of Example D and 2.75 g (0.025 mol) of thionyl chloride in benzene (60 ml). The crude product was chromatographed on silica gel using 5% ethyl acetate/hexane to give two sets of two racemates. The less polar pair of racemates weighed 0.62 g. The more polar pair of racemates weighed 1.3 g.

Provenance & Evidence