HCID 19849033, compound → HCID 19849018, compound

Participants

Reaction Steps

A stirred slurry of potassium thioacetate (1.14 g, 10 mmol) in a solution of the tosylate of Example P (4.15 g, 10 mmol) in acetone (30 ml) is refluxed under nitrogen for 5 hrs. The reaction mixture is filtered and the filtrate is concentrated on a rotary evaporator. The residue is dissolved in ethyl acetate, washed with water and dried over sodium sulfate. The drying agent is filtered, the solvent is removed using the rotary evaporator and the residue is chromatographed on silica gel using mixtures of ethyl acetate and hexane as eluents to give the titled compound.

Provenance & Evidence