Lithium Hydroxide → HCID 19849038, compound

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Reaction Steps

The ester of Example 13 (4.87 g, 10 mmol) is stirred overnight at room temperature under N2 with aqueous LiOH solution (2M, 13 ml) in methanol (60 ml). The reaction is concentrated on a rotary evaporator and the residue diluted with water. The resulting solution is washed once with ethyl ether and then acidified to pH 2.5 with 0.5N KHSO4 solution. The aqueous mixture is extracted with ethyl acetate and the organic layer dried over MgSO4.

Provenance & Evidence