HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic acid, 2-hydrazinyl-, ethyl ester, hydrochloride (1:1) → Ethyl 4-(4-methoxyphenyl)-5-phenyl-1H-pyrazole-1-acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic acid, 2-hydrazinyl-, ethyl ester, hydrochloride (1:1) | HCID 11593468 | — |
| Reactant | 3-(Dimethylamino)-2-(4-methoxyphenyl)-1-phenyl-2-propene-1-one | HCID 54111243 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Ethyl 4-(4-methoxyphenyl)-5-phenyl-1H-pyrazole-1-acetate | HCID 14699555 | — |
Reaction Steps
Following the procedure of example 1B 11 g (0.39 mol) of 3-(dimethylamino)-2-(4-methoxyphenyl)-1-phenyl-2-propene-1-one and 6.6 g (0.43 mol) of ethyl hydrazinoacetate hydrochloride were reacted in 55 mL of absolute methanol under nitrogen. After 11/2 hours, 11.2 g of solid product was filtered off, mp 81°-84° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04870095 |
| Source dataset | uspto-grants-1989_09 |
| ORD ID | ord-49ab6fddc2a046c293612e4a1a35f1c4 |
| Source note | uspto-grants-1989_09 |