反应详情

A solution of 8.73 g (0.027 mol) of ethyl 4-(4-fluorophenyl)-5-phenyl-1H-pyrazole-1-acetate of example 7 in 30 mL of 3-(diethylamino)propanamine was heated at reflux for 3 hr. The excess amine was stripped under vacuum and the residue triturated in 1:1 hexane/methyl t-butyl ether. The solid was recrystallized from triethylamine to yield 8.4 g of product, mp 82°-83° C.

1. temperatureat reflux for 3 hr
2. customthe residue triturated in 1:1 hexane/methyl t-butyl ether
3. customThe solid was recrystallized from triethylamine