Ammonium formate → HCID 14723691, compound

Participants

Reaction Steps

A solution of 43.7 g (0.1 mol) of N-[3-(diethylamino)propyl]-4-(4-nitrophenyl)-5-phenyl-1H-pyrazole-1-acetamide of example 45 in 200 mL of methanol was refluxed for 2 hr with 4 g of 10% palladium on charcoal and 30 g of ammonium formate. The catalyst was filtered off and the filtrate was stripped. The residue was distributed between aqueous NaOH and 1:1 THF-ether. The ether layer was dried over magnesium sulfate, stripped and recrystallized from methyl t-butyl ether to yield 38.9 g of product, mp 75°-76° C.

Provenance & Evidence