2,3-Dichloro-5,6-dicyano-1,4-benzoquinone → HCID 19849123, compound

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Reaction Steps

Dichlorodicyanobenzoquinone (DDQ) 4.5 g (19.8 mM) was added to the compound 925 5 g (18 mM) dissolved in benzene 300 ml with heating, and the mixture was refluxed for 3 hours. The reaction mixture was filtered hot and then the filtrate was concentrated in vacuo. The residue, dissolved in chloroform, was washed with water, dried by adding anhydrous sodium sulfate and concentrated in vacuo. The residue was charged on a column of silica gel (C-200) packed with chloroform, and purified by eluting with chloroform-methanol (300:1), (200:1) and (100:1), in this order to obtain the compound 914 as colorless crystals.

Provenance & Evidence