HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 178472019, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | beta-Alanine, ethyl ester, hydrochloride | HCID 458475 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | Ethyl 3-ethoxy-2-(2,3,4,5-tetrafluorobenzoyl)acrylate | HCID 54346083 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 178472019 | HCID 178472019 | — |
Reaction Steps
6.4 g of ethyl 3-ethoxy-2-(2,3,4,5-tetrafluoro-benzoyl)acrylate are initially introduced into 30 ml of methylene chloride. A solution of 3.1 g of ethyl 3-amino-propionate hydrochloride in 12 ml of water is added to this. A solution of 1.7 g of NaHCO3 in 20 ml of water is added dropwise to the two-phase mixture with vigorous stirring. After the dropwise addition is complete, the mixture is stirred for a further 3 hours. The phases are then separated, and the organic phase is washed with water and dried over Na2SO4. After concentration, 7.8 g of the title compound remain. Melting point: 96°-97° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04870182 |
| Source dataset | uspto-grants-1989_09 |
| ORD ID | ord-9338e109b5e84b3187d6814c852dba9d |
| Source note | uspto-grants-1989_09 |