Ammonia → HCID 178472080, compound

HRID 1608357Notes

Reaction equation

HRID 1608357 reaction equation
[Cl:1][C:2]1[C:19]([N+:20]([O-:22])=[O:21])=[C:18]([Cl:23])[C:17]([F:24])=[CH:16][C:3]=1[C:4]([C:6](=[CH:12]OCC)[C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5].[NH3:25]>C(O)C>[NH2:25][CH:12]=[C:6]([C:4](=[O:5])[C:3]1[CH:16]=[C:17]([F:24])[C:18]([Cl:23])=[C:19]([N+:20]([O-:22])=[O:21])[C:2]=1[Cl:1])[C:7]([O:9][CH2:10][CH3:11])=[O:8]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 53944414Ethyl 2-(2,4-dichloro-5-fluoro-3-nitrobenzoyl)-3-ethoxyacrylate

Product 1

HCID 178472080HCID 178472080, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

38 g of the product from Example 1 are initially introduced into 40 ml of ethanol. A mixture of 8 ml of concentrated NH3 solution in 25 ml of ethanol is added dropwise with ice cooling. The mixture is stirred for 2 hours at room temperature and the phases are then separated. The organic phase is washed with water and dried. 38.3 g of the title compound remain on concentration. Melting point: 113°-114° C.

Workup

  1. additionis added dropwise with ice cooling
  2. customthe phases are then separated
  3. washThe organic phase is washed with water
  4. customdried
  5. concentration38.3 g of the title compound remain on concentration

Sources & evidence

ORD record
ord-dcdf6d6a178d4551a6037737166399ba
Source dataset
uspto-grants-1989_09
Patent number
US04870182

Reaction notes

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