反应详情

12.8 g of ethyl 3-ethoxy-2-(2,3,4,5-tetrafluoro-benzoyl)-acrylate are initially introduced into 16 ml of EtOH. A mixture of 3.3 ml of concentrated aqueous NH3 solution and 10 ml of EtOH is added dropwise with ice cooling. The mixture is subsequently stirred for 2 hours. Ice-water is then added, and the precipitated solid is filtered off under suction. Yield: 8.7 g, melting point: 118°-119° C.

1. additionis added dropwise with ice cooling
2. filtrationthe precipitated solid is filtered off under suction