Ammonia → HCID 178472081, compound

HRID 1608359Notes

Reaction equation

HRID 1608359 reaction equation
C(O[CH:4]=[C:5]([C:11](=[O:22])[C:12]1[CH:17]=[C:16]([F:18])[C:15]([F:19])=[C:14]([F:20])[C:13]=1[F:21])[C:6]([O:8][CH2:9][CH3:10])=[O:7])C.[NH3:23]>CCO>[NH2:23][CH:4]=[C:5]([C:11](=[O:22])[C:12]1[CH:17]=[C:16]([F:18])[C:15]([F:19])=[C:14]([F:20])[C:13]=1[F:21])[C:6]([O:8][CH2:9][CH3:10])=[O:7]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 54346083Ethyl 3-ethoxy-2-(2,3,4,5-tetrafluorobenzoyl)acrylate

Product 1

HCID 178472081HCID 178472081, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

12.8 g of ethyl 3-ethoxy-2-(2,3,4,5-tetrafluoro-benzoyl)-acrylate are initially introduced into 16 ml of EtOH. A mixture of 3.3 ml of concentrated aqueous NH3 solution and 10 ml of EtOH is added dropwise with ice cooling. The mixture is subsequently stirred for 2 hours. Ice-water is then added, and the precipitated solid is filtered off under suction. Yield: 8.7 g, melting point: 118°-119° C.

Workup

  1. additionis added dropwise with ice cooling
  2. filtrationthe precipitated solid is filtered off under suction

Sources & evidence

ORD record
ord-eaf7f91e264b4a42a52d0cd301592bf8
Source dataset
uspto-grants-1989_09
Patent number
US04870182

Reaction notes

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