HCID 178472081, compound → 3-Quinolinecarboxylic acid, 1,4-dihydro-4-oxo-6,7,8-trifluoro-, ethyl ester

HRID 1608360Notes

Reaction equation

HRID 1608360 reaction equation
[NH2:1][CH:2]=[C:3]([C:9](=[O:20])[C:10]1[CH:15]=[C:14]([F:16])[C:13]([F:17])=[C:12]([F:18])[C:11]=1F)[C:4]([O:6][CH2:7][CH3:8])=[O:5]>O1CCOCC1>[F:18][C:12]1[CH:11]=[C:10]2[C:15](=[C:14]([F:16])[C:13]=1[F:17])[N:1]=[CH:2][C:3]([C:4]([O:6][CH2:7][CH3:8])=[O:5])=[C:9]2[OH:20]

Participants

3

Reactant 1

HCID 178472081HCID 178472081, compound

Product 1

HCID 27339723-Quinolinecarboxylic acid, 1,4-dihydro-4-oxo-6,7,8-trifluoro-, ethyl ester

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

5.8 g of the product from Example 10 are initially introduced into 25 ml of dioxane. 4.8 g of potassium tert.-butylate are added in portions at room temperature.

Sources & evidence

ORD record
ord-d3f9cb96e0a441f6b0869ff918ac11df
Source dataset
uspto-grants-1989_09
Patent number
US04870182

Reaction notes

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