Ethyl 7-chloro-6-fluoro-4-hydroxy-8-nitro-3-quinolinecarboxylate → HCID 178469663, compound

Participants

Reaction Conditions

Reaction Steps

9.4 g of the product from Example 5 and 19.2 g of iron turnings are warmed at 80° C. for 1 hour in 190 ml of acetic acid. The mixture is then heated briefly to 110° C. and filtered while hot. Ice-water is then added to the filtrate, and the precipitated solid is isolated. After drying at 110° C., the product is recrystallized from glycol monomethyl ether. Yield: 7.8 g, melting point: 268°-70° C.

Provenance & Evidence