Formaldehyde → HCID 14794090, compound

Participants

Reaction Conditions

Reaction Steps

In a 1 liter stainless steel autoclave was placed 440 ml methanol, 19.6 g (0.65 mole) paraformaldehyde, 5.3 g (0.048 mole) 40 percent aqueous dimethylamine catalyst and 82.4 g (0.5 mole) 2-methyl-6-tert-butylphenol. The autoclave was sealed and heated while stirring to 130° C. Stirring was continued at 130° C. for 3 hours 10 minutes. Analysis by gas chromatograph (GC) showed the reaction forming 2-methyl-6-tert-butyl-4-methoxymethylphenol to be 95 percent complete. The mixture was transferred to a distillation flask under nitrogen and the excess methanol was distilled out up to a flask temperature of 100° C. The residue was cooled and dissolved in 290 g methylene chloride.

Provenance & Evidence