HCID 14877952, compound → HCID 14877953, compound

HRID 1608407Notes

Reaction equation

HRID 1608407 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:17]2[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=2)=[C:9]([N:12]2[CH:16]=[N:15][N:14]=[N:13]2)[CH2:10][OH:11])=[CH:4][CH:3]=1.[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1>C(Cl)Cl>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:17]2[CH:18]=[CH:19][C:20]([F:23])=[CH:21][CH:22]=2)=[C:9]([N:12]2[CH:16]=[N:15][N:14]=[N:13]2)[CH:10]=[O:11])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 14877952HCID 14877952, compoundHCID 178418287HCID 178418287, compound

Product 1

HCID 14877953HCID 14877953, compoundYield 56%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Following the general procedure of Example 6, 0.21 g (0.67 mmole) of 3,3-bis(4-fluorophenyl)-2-(1H-tetrazol-1-yl)-2-propenol was treated with 288 mg (1.33 mmoles) of pyridinium chlorochromate in 10 mL of methylene chloride and there was thereby produced 117 mg (56%) of the title compound after crystallization from ethyl acetate-hexanes; m.p. 160.7°-161.4° C.

Sources & evidence

ORD record
ord-daf5ece685af4b59b7360a4d9f7f21ef
Source dataset
uspto-grants-1989_09
Patent number
US04870187

Reaction notes

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