HCID 20085922, compound → HCID 20085919, compound

Participants

Reaction Steps

Methyl 5-bromo-2-(4 -bromophenoxymethyl)benzoate (90 g, 0.23 mole) was refluxed in a mixture of 100 mL of 10% sodium hydroxide and 200 mL of methanol for three hours. The reaction mixture was concentrated under reduced pressure and water was added to the residue. The mixture was acidified with concentrated hydrochloric acid. A solid was precipitated and collected as the acid product (80 g). mp 214°-215° C. pmr (DMSO-d6) δ: 6.76-8.01 (m, 7H, aromatic H), 5.38 (s, 2H, ArCH2O).

Provenance & Evidence