Boron tribromide → HCID 67277099, compound

HRID 16085Notes

Reaction equation

HRID 16085 reaction equation
B(Br)(Br)Br.[Cl:5][C:6]1[CH:7]=[CH:8][C:9]([O:31]CC2C=CC=CC=2)=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([S:18]([N:21]3[CH2:26][CH2:25][O:24][CH2:23][CH2:22]3)(=[O:20])=[O:19])=[C:14]([C:27]([F:30])([F:29])[F:28])[CH:13]=2)[CH:11]=1>C(Cl)Cl>[Cl:5][C:6]1[CH:7]=[CH:8][C:9]([OH:31])=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([S:18]([N:21]3[CH2:26][CH2:25][O:24][CH2:23][CH2:22]3)(=[O:20])=[O:19])=[C:14]([C:27]([F:28])([F:29])[F:30])[CH:13]=2)[CH:11]=1

Participants

4

Reactant 2

HCID 25134Boron tribromideHCID 131728176HCID 131728176, compound

Product 1

HCID 67277099HCID 67277099, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Boron tribromide (2.5 ml, 1.0 M in DCM) was added to a solution of the product from step b) (1.16 g) in DCM (15 ml) at 0° C. The solution was stirred for 15 min then quenched with water. The mixture was extracted with DCM (three times), the organic extracts were dried (MgSO4), evaporated and purified by chromatography (silica, petrol-ether as eluent) to give the sub-title compound (851 mg).

Workup

  1. customthen quenched with water
  2. extractionThe mixture was extracted with DCM (three times)
  3. dry with materialthe organic extracts were dried (MgSO4)
  4. customevaporated
  5. custompurified by chromatography (silica, petrol-ether as eluent)

Sources & evidence

ORD record
ord-318a9a580f944ee1ad8fc99184b7b8b6
Source dataset
uspto-grants-2010_06
Patent number
US07737135B2

Reaction notes

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