Ethanol → HCID 54093137, compound

Participants

Reaction Steps

In 10 ml of ethanol was dissolved 850 mg of N-benzyloxycarbonyl-L-leucine-(1-formyl)pentylamide obtained in the same manner as in Example 4-(b), and 2 ml of water and 1.0 g of semicarbazide hydrochloride were added thereto, followed by stirring at room temperature for 2 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was purified by medium-pressure column chromatography on silica gel to obtain 900 mg of the titled compound as a colorless crystal.

Provenance & Evidence