Pyridine → HCID 88393073, compound

Participants

Reaction Steps

In 30 ml of ethanol was dissolved 750 mg of N-acetyl-L-leucine-(1-formyl)pentylamide obtained in the same manner as in Example 16-(c), and 210 mg of hydroxyammonium chloride and 5 ml of pyridine were added thereto. The mixture was allowed to react at room temperature for 24 hours. After completion of the reaction, the reaction mixture was washed with a saturated brine and dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure, and the residue was purified by mediumpressure column chromatography on silica gel to obtain 600 mg of the titled compound as a colorless crystal.

Provenance & Evidence