Water → HCID 54509996, compound

Participants

Reaction Steps

In 20 ml of ethanol was dissolved 750 mg of N-acetyl-L-leucine-(1-formyl)pentylamide obtained in the same manner as in Example 16-(c), and 1.5 g of sodium acetate, 1.0 g of semicarbazide hydrochloride, and 1 ml of water were added thereto. The mixture was allowed to react at room temperature for 24 hours. After completion of the reaction, the reaction mixture was washed with a saturated brine and dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure, and the residue was purified by medium-pressure column chromatography on silica gel to obtain 550 mg of the titled compound as a colorless crystal.

Provenance & Evidence