3-Nitrobenzylamine → HCID 136145659, compound

HRID 1608532Notes

Reaction equation

C(OC[N:9]1[C:18](=[O:19])[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([CH2:20][N:21]([C:25]3[CH:33]=[CH:32][C:28]([C:29]([OH:31])=O)=[CH:27][CH:26]=3)[CH2:22][C:23]#[CH:24])[CH:16]=2)[N:11]=[CH:10]1)(=O)C(C)(C)C.[N+:34]([C:37]1[CH:38]=[C:39]([CH:42]=[CH:43][CH:44]=1)[CH2:40][NH2:41])([O-:36])=[O:35]>>[O:19]=[C:18]1[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([CH2:20][N:21]([C:25]3[CH:33]=[CH:32][C:28]([C:29]([NH:41][CH2:40][C:39]4[CH:42]=[CH:43][CH:44]=[C:37]([N+:34]([O-:36])=[O:35])[CH:38]=4)=[O:31])=[CH:27][CH:26]=3)[CH2:22][C:23]#[CH:24])[CH:16]=2)[N:11]=[CH:10][NH:9]1

Participants

Reactant 2

HCID 1227223-Nitrobenzylamine

HCID 15079291HCID 15079291, compound

Product 1

HCID 136145659HCID 136145659, compoundYield 56%

Procedure

Using the procedure described in Example 10, p-[N-(3,4-dihydro-3-pivaloyloxymethyl-4-oxoquinazolin-6-ylmethyl)-N-(prop-2-ynyl)amino]benzoic acid was reacted with 3-nitrobenzylamine to give p-[N-(3,4-dihydro-4-oxoquinazolin-6-ylmethyl)-N-(prop-2-ynyl)amino]-N-(3-nitrobenzyl)benzamide (containing 1 equivalent of water, 56%), m.p. 197°-199° C.

Sources & evidence

ORD record: ord-e235c46a389a46b3abb414d467e82ec0
Source dataset: uspto-grants-1995_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05395838

Reaction notes

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