2-(Trifluoromethyl)-1,3-thiazole-4-carbaldehyde → HCID 54139485, compound

HRID 1608536Notes

Reaction equation

HRID 1608536 reaction equation
[F:1][C:2]([F:11])([F:10])[C:3]1[S:4][CH:5]=[C:6]([CH:8]=[O:9])[N:7]=1.[CH3:12][Mg]Br>CCCCCC.C(OCC)(=O)C>[F:11][C:2]([F:1])([F:10])[C:3]1[S:4][CH:5]=[C:6]([CH:8]([OH:9])[CH3:12])[N:7]=1

Participants

4

Reactant 2

HCID 200867172-(Trifluoromethyl)-1,3-thiazole-4-carbaldehydeHCID 178418573HCID 178418573, compound

Product 1

HCID 54139485HCID 54139485, compound

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

Using the procedure of Example 1, 2-trifluoromethyl-4-thiazolecarboxaldehyde and methyl magnesium bromide were reacted to obtain the desired product with a Rf=0.17 [hexane-ethyl acetate (7-3)].

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-37bb0f6d669d4781a0923ac247be5645
Source dataset
uspto-grants-1995_03
Patent number
US05395845

Reaction notes

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