2-Bromo-1,3-thiazole-4-carboxaldehyde → HCID 20086738, compound

HRID 1608537Notes

Reaction equation

HRID 1608537 reaction equation
[Br:1][C:2]1[S:3][CH:4]=[C:5]([CH:7]=[O:8])[N:6]=1.[C:9]([Mg]Br)#[CH:10]>CCCCCC.C(OCC)(=O)C>[Br:1][C:2]1[S:3][CH:4]=[C:5]([CH:7]([C:9]#[CH:10])[OH:8])[N:6]=1

Participants

4

Reactant 2

HCID 177504332-Bromo-1,3-thiazole-4-carboxaldehydeHCID 178418486HCID 178418486, compound

Product 1

HCID 20086738HCID 20086738, compound

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

Using the procedure of Example 1, 2-bromo-4-thiazole carboxaldehyde and ethynyl magnesium bromide were reacted to obtain the desired product with a Rf=0.17 [hexane-ethyl acetate (7-3)].

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-1d70cc066f4c4babb3b4cc3b9652fd1e
Source dataset
uspto-grants-1995_03
Patent number
US05395845

Reaction notes

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