HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[[(tetrahydro 2H-pyran-2-yl) oxy] methyl] 2-thiazole carboxaldehyde → alpha-ethynyl 4-[[(tetrahydro 2H-pyran-2-yl) oxy] methyl] 2-thiazole methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[[(tetrahydro 2H-pyran-2-yl) oxy] methyl] 2-thiazole carboxaldehyde | HCID 54248309 | — |
| Reactant | HCID 178418486 | HCID 178418486 | — |
| Solvent | Ethyl acetate hexane | HCID 21226206 | — |
| Product | alpha-ethynyl 4-[[(tetrahydro 2H-pyran-2-yl) oxy] methyl] 2-thiazole methanol | HCID 53736243 | — |
Reaction Steps
The product was prepared starting with the product of Stage B and ethynyl magnesium bromide using the procedure of Example 1 to obtain the desired product with a Rf=0.11 (hexane-ethyl acetate (7-3)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05395845 |
| Source dataset | uspto-grants-1995_03 |
| ORD ID | ord-4fe8586dde454c96aa6deeca9303f204 |
| Source note | uspto-grants-1995_03 |