HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 4-Thiazolemethanol, 2-ethynyl-(9CI)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | (2-Bromo-1,3-thiazol-4-yl)methanol | HCID 2763211 | — |
| Catalyst | Copper iodide | HCID 83717 | — |
| Catalyst | Dichlorobis(triphenylphosphine)palladium | HCID 6102075 | — |
| Product | 4-Thiazolemethanol, 2-ethynyl-(9CI) | HCID 45079328 | — |
Reaction Steps
2-bromo 4-thiazolyl methanol of preparation 39 was reacted with trimethylacetylene in the presence of copper iodide, bis(triphenylphosphine) palladium chloride and triethylamine and then the mixture was poured into an aqueous solution of ammonium chloride to obtain the expected alcohol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05395845 |
| Source dataset | uspto-grants-1995_03 |
| ORD ID | ord-6b8b2977c0c04148a5728397ca6830b2 |
| Source note | uspto-grants-1995_03 |