4-Hydroxybenzaldehyde → HCID 135714966, compound

Participants

Reaction Steps

Under a nitrogen atmosphere, p-hydroxybenzaldehyde (99.6 g), n-octadecylamine (200.0 g) and p-toluenesulfonic acid (13.4 g) were added to toluene (1200 ml) and the mixture was refluxed with heating and simultaneously the azeotropic water was removed. After about 2 hours, the reaction mixture was cooled to room temperature to precipitate a crystal, which was filtered off under reduced pressure. This crystal was recrystallized from isopropanol to obtain the desired product (207.9 g). Yield 75%; m.p. 101° C.

Provenance & Evidence