反应详情

After a suspension of 5-[2-(amino)ethylthio]imidazo[1,2-a]pyridine.dihydrochloride (13.31 g, 50 mmoles) in chloroform (200 ml) was washed with 3N-sodium hydroxide (50 ml), the aqueous layer was extracted with chloroform, combined the chloroform layer was dried over anhydrous magnesium sulfate. After the solvent was distilled off to obtain 9.63 g of the desired product (99.7%, pale yellow oily product).

1. washwas washed with 3N-sodium hydroxide (50 ml)
2. extractionthe aqueous layer was extracted with chloroform
3. dry with materialwas dried over anhydrous magnesium sulfate
4. distillationAfter the solvent was distilled off