Potassium Carbonate → HCID 53896186, compound

Participants

Reaction Steps

0.75 g (3.3 mmoles) of 4-chloro-2-methyl-5-(1-piperazinyl)-3(2H)-pyridazinone prepared as described hereinafter under the title "Preparation of the starting substances" and 0.91 g (6.6 mmoles) of anhydrous potassium carbonate are suspended in 5 ml of anhydrous dimethyl formamide. Then a solution of 0.5 g (3.3 moles) of 3-phenyl-2-propenyl chloride in 5 ml of anhydrous dimethyl formamide are dropped to the suspension, and the reaction mixture is stirred at room temperature for 24 hours. The dimethyl formamide is evaporated in vacuo, a slight amount of water is added to the residue and the solution thus obtained is extracted with ethyl acetate. The organic phase is dried and evaporated and the residue is crystallized from ethanol. Thus 0.55 g (49%) of the desired compound is obtained. M.p.: 98°-100° C. Its monohydrochloride salt melts at 218°-220° C.

Provenance & Evidence