Ammonia → HCID 20086985, compound

Participants

Reaction Steps

A mixture of 3.2 g (9.5 mmoles) of 2-benzyloxymethyl-5-chloro-4-[3-(N-methylamino)-propylamino]-3(2H)-pyridazinone, 3.56 g (14.25 mmoles) of 4-[(methylsulfonyl)-amino]-phenoxyethyl chloride and 2 ml (14.25 mmoles) of triethylamine is melted at a temperature of 80° C. for 16 hours. Then it is subjected to column chromatography using first ethyl acetate, then a 9:1:0.5 mixture of ethyl acetate--methanol--cc. ammonia. Thus 1.8 g (69%) of the aimed compound are obtained. Rf =0.7.

Provenance & Evidence