Dichloromethane → HCID 20086988, compound

Participants

Reaction Steps

0.48 g (2.2 mmoles) of 5-chloro-4-[N-(3-hydroxypropyl)-amino]-2-methyl-3(2H)-pyridazinone is dissolved in ml of dichloromethane, and 2.1 ml (28.8 mmoles) of thionyl chloride are dropped to the solution. Then it is boiled for 3 hours under stirring and reflux cooling. The solvent is evaporated and the crude product thus obtained is triturated with ether. Thus 0.38 g (73%) of the desired compound is obtained. M.p.: 91°-92° C.

Provenance & Evidence