p-Toluenesulfonic acid → HCID 86748549, compound

Participants

Reaction Steps

To a solution of 36 mg of (4S)-5-(2-acetamidoethoxycarbonyl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3-carboxylic acid in 0.5 ml of tetrahydrofuran were added 7.7 mg of p-toluenesulfonic acid, and then 0.24 ml of 3,4-dihydro-2-H-pyrane. The mixture was stirred at room temperature for 6 hours. The reaction mixture was diluted with 5 ml of ethyl acetate, washed with saturated aqueous sodium hydrogen carbonate solution and with water, and dried over anhydrous Glauber's salt (sodium sulfate), followed by distilling off the solvent under reduced pressure. The residue was purified using preparative TLC to obtain 18 mg of the objective compound.

Provenance & Evidence