Formaldehyde → HCID 131718919, compound

HRID 1608703Notes

Reaction equation

HRID 1608703 reaction equation
[CH3:1][S:2]([O:5][CH2:6][C@H:7]([C@@H:9]([CH2:11][O:12][S:13]([CH3:16])(=[O:15])=[O:14])[OH:10])[OH:8])(=[O:4])=[O:3].[CH2:17]=O.S(=O)(=O)(O)O>>[CH3:16][S:13]([O:12][CH2:11][C@@:9]1([CH2:17][O:8][C@@H:7]1[CH2:6][O:5][S:2]([CH3:1])(=[O:3])=[O:4])[OH:10])(=[O:15])=[O:14]

Participants

4

Reactant 3

HCID 712FormaldehydeHCID 1118Sulfuric AcidHCID 958391947-62-2

Product 1

HCID 131718919HCID 131718919, compoundYield 61%

Procedure

D-threitol 1,4-bis(methanesulfonate) was reacted with formaldehyde and concentrated sulfuric acid as described in J. Med. Chem., 7, 14 (1964) to yield 2,3-O-methylene-D-threitol 1,4-bis(methanesulfonate) in 61% yield.

Sources & evidence

ORD record
ord-9df0e6087cc84391ba5107b06542e82e
Source dataset
uspto-grants-1995_03
Patent number
US05395947

Reaction notes

Loading…