反应详情

1.00 g (8.76 mmol) of (1R,2R)-(-)-1,2-cyclohexanediamine of [α]D20 =-36.7° (c 4.14, H2O) and 1.02 g (8.78 mmol) of dl-trans-1,2-cyclohexanediol were added to 3 ml of toluene and then heated/dissolved therein, and the solution was cooled to room temperature. Afterward, the precipitated crystals were collected by filtration and then recrystallized from 3 ml of toluene twice to obtain 0,485 g of (1R,2R)-(-)-1,2-cyclohexanediamine-(1R,2R)-(-)-1,2-cyclohexanediol. Physical properties of the product are as follows.

1. dissolutionheated/dissolved
2. filtrationAfterward, the precipitated crystals were collected by filtration
3. customrecrystallized from 3 ml of toluene twice