反应详情

To a solution of N-propylaniline (60 g) and ethyl bromoacetate (83.6 ml) in dioxane (60 ml), diazabicycloundecene (DBU;113 ml) was added dropwise under ice-cooling. After stirring for 1 hour at room temperature, the reaction mixture was diluted with water and extracted three times with ethyl acetate. The combined organic layer was washed with successive, 1N hydrochloric acid, water and saturated sodium chloride in order. After drying over anhydrous sodium sulfate, the solvent was evaporated under reduced pressure to give 87.9 g (90%) of the objective compound.

1. temperaturecooling
2. extractionextracted three times with ethyl acetate
3. washThe combined organic layer was washed with successive, 1N hydrochloric acid, water and saturated sodium chloride in order
4. dry with materialAfter drying over anhydrous sodium sulfate
5. customthe solvent was evaporated under reduced pressure