反应详情

The titled compound was prepared substantially in accordance with the method detailed in Example 11 using 2.00 g (0.00869 mol) of 2-amino-N-[2-(1H-imidazol-2-yl)-ethyl]benzamide, prepared as in Example 6A, and 2.74 g (0.01738 mol) of p-toluoyl chloride with the exception that after removing ethyl acetate the resultant solid was purified by crystallization from an ethyl acetate/hexane solution containing a small amount of methanol, followed by recrystallization from an ethyl acetate/methanol solution, to provide 2.17 g of the desired titled compound (m.p. 209°-214° C.).

1. customThe titled compound was prepared substantially in accordance with the method
2. customthat after removing ethyl acetate the resultant solid
3. customwas purified by crystallization from an ethyl acetate/hexane solution
4. additioncontaining a small amount of methanol
5. customfollowed by recrystallization from an ethyl acetate/methanol solution