Isatoic Anhydride → HCID 178507502, compound

Participants

Reaction Steps

The subtitled compound was prepared substantially in accordance with the method detailed in Example 6A using 5.55 g (0.05 mol) of 4-(2-aminoethyl)imidazole in 40 ml ethanol and 8.31 g (0.05 mol) of isatoic anhydride with the exception that after removing ethanol from the reaction solution the product was purified using column chromatography (500 ml dichloromethane; 2000 ml 9% methanol in dichloromethane, isocratic eluent). The fractions containing the desired product were combined and reduced to dryness under reduced pressure to provide a solid. This solid was recrystallized from diethyl ether to provide 1.65 g of the desired subtitled compound (m.p. 85°-87° C.).

Provenance & Evidence