Sodium Hydroxide → HCID 23368657, compound

HRID 1608851Notes

Reaction equation

HRID 1608851 reaction equation
[S:1]([N:11]([C:18]1[CH:32]=[CH:31][C:30]([Cl:33])=[CH:29][C:19]=1[C:20]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[Cl:28])=[O:21])[CH2:12][C:13](=[O:17])[N:14]([CH3:16])[CH3:15])([C:4]1[CH:10]=[CH:9][C:7]([CH3:8])=[CH:6][CH:5]=1)(=[O:3])=[O:2].[OH-].[Na+]>C(#N)C.O.[Cl-].C([N+](CC)(CC)CC)C1C=CC=CC=1>[CH3:16][N:14]([CH3:15])[C:13]([CH:12]1[C:20]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[Cl:28])([OH:21])[C:19]2[C:18](=[CH:32][CH:31]=[C:30]([Cl:33])[CH:29]=2)[N:11]1[S:1]([C:4]1[CH:10]=[CH:9][C:7]([CH3:8])=[CH:6][CH:5]=1)(=[O:3])=[O:2])=[O:17]

Participants

6

Reactant 2

HCID 14798Sodium HydroxideHCID 23368712HCID 23368712, compound

Product 1

HCID 23368657HCID 23368657, compound

Reagents, catalysts & solvents 3

HCID 66133Benzyl triethylammonium chlorideCatalystHCID 962WaterSolventHCID 6342AcetonitrileSolvent

Conditions

Temperature
45 °C

Procedure

The compound of step B (1.0 g) is dissolved in acetonitrile (25 ml), and 109 mg of sodium hydroxide in 2 ml of water are added. The medium is heterogeneous; it is stirred violently at 45° C. for 1 hour, using a turbine and compressed air, either in the presence of 110 mg of benzyltriethylammonium chloride or without the addition of this reagent.

Sources & evidence

ORD record
ord-05ad68a3acb04feea6d926d37fb09ca8
Source dataset
uspto-grants-1995_03
Patent number
US05397801

Reaction notes

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