2,3-Dimethyl-3H-imidazo[4,5-b]pyridine → HCID 178433622, compound

HRID 1608873Notes

Reaction equation

HRID 1608873 reaction equation
[IH:1].[F:2][C:3]([F:8])([F:7])[C:4]([O-:6])=[O:5].[NH2:9][C:10]1[S:11][CH:12]=[C:13]([C:15]([C:49]2[CH:54]=[CH:53][C:52]([OH:55])=[C:51]([OH:56])[CH:50]=2)([O:19][N:20]=[CH:21][C:22]([NH:24][CH:25]2[C:32](=[O:33])[N:31]3[CH:26]2[S:27][CH2:28][C:29]([CH:37]=[CH:38][CH2:39][N+:40]2[CH:45]=[CH:44][C:43]4SC=C[C:42]=4[CH:41]=2)=[C:30]3[C:34]([OH:36])=[O:35])=[O:23])[C:16]([OH:18])=[O:17])[N:14]=1.[CH3:57][C:58]1[N:59](C)[C:60]2N=CC=CC=2[N:62]=1>>[IH:1].[F:2][C:3]([F:8])([F:7])[C:4]([O-:6])=[O:5].[NH2:9][C:10]1[S:11][CH:12]=[C:13]([C:15]([C:49]2[CH:54]=[CH:53][C:52]([OH:55])=[C:51]([OH:56])[CH:50]=2)([O:19][N:20]=[CH:21][C:22]([NH:24][CH:25]2[C:32](=[O:33])[N:31]3[CH:26]2[S:27][CH2:28][C:29]([CH:37]=[CH:38][CH2:39][N:40]2[CH:45]=[CH:44][C:43]4=[NH+:62][CH:58]([CH3:57])[N:59]([CH3:60])[C:42]4=[CH:41]2)=[C:30]3[C:34]([OH:36])=[O:35])=[O:23])[C:16]([OH:18])=[O:17])[N:14]=1

Participants

3

Reactant 2

HCID 124540212,3-Dimethyl-3H-imidazo[4,5-b]pyridineHCID 86748556HCID 86748556, compound

Product 1

HCID 178433622HCID 178433622, compoundYield 45%

Procedure

Using the procedure of Step A of Example 20, 1.92 g of the product of Step B of Example 11 and 303 mg of 2,3-dimethyl-4-azabenzimidazole were reacted to obtain 877 mg of the expected product.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-bcfc57abbfa0460ba6a0759f7a63b461
Source dataset
uspto-grants-1995_03
Patent number
US05397779

Reaction notes

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